Introduction to ENBREL SureClick Autoinjector

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Step 1: Prepare

A. Remove one ENBREL SureClick Autoinjector from the package.

Carefully lift the autoinjector straight up out of the carton.

Before you inject, always check the label of the autoinjector to make sure you have the correct medicine and the correct dose of ENBREL.

Put the original package with any unused autoinjectors back in the refrigerator. You may also store the unused autoinjectors at room temperature, up to 27°C, for up to 60 days.

Wait at least 30 minutes for the autoinjector to reach room temperature before injecting.

This is important for administering the full dose and helps minimize discomfort.

ENBREL may take longer to inject if it has not reached room temperature. Do not heat the autoinjector. Let it come to room temperature naturally.

  • Do not put autoinjector back in the refrigerator after it has reached room temperature.
  • Do not to warm autoinjector by using a heat source such as hot water or microwave.
  • Do not leave autoinjector in direct sunlight.
  • Do not shake autoinjector.
  • Do not remove the white cap from autoinjector yet.

B. Inspect the ENBREL SureClick Autoinjector.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL

Make sure the medicine in the window is clear and colourless.

  • It is okay if you see small white particles in the medicine.
  • Do not use the autoinjector if:
  • the medicine is cloudy or discoloured or contains large lumps, flakes or coloured particles;
  • any part appears cracked or broken;
  • the autoinjector has been dropped;
  • the white cap is missing or not securely attached;
  • the expiration date printed on the label has passed.

In all cases, use a new autoinjector and call 1.877.9ENBREL (1.877.936.2735), weekdays 8:00 am to 8:00 pm EST.

C. Gather all materials needed for your injection.

Wash your hands thoroughly with soap and water. On a clean, well-lit work surface, place the:

  • New autoinjector
  • Alcohol wipes
  • Cotton balls or gauze pads
  • Adhesive bandages
  • Sharps disposal container

To order alcohol swabs, call Amgen Entrust at 1.877.9ENBREL (1.877.936-2735), weekdays 8:00 am to 8:00 pm EST.

D. Prepare and clean your injection site.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL

You can use the:

  • Thigh
  • Stomach, except for a 2-inch area around your belly button
  • Outer area of upper arm (only if someone else is giving you the injection)
  • Clean the injection site with an alcohol wipe. Let your skin dry.
  • Do not touch this area again before injecting
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Choose a different site each time you give yourself an injection. If you need to use the same injection site, just make sure it is not the same spot on the site you used last time (at least one inch away from the site that was used before).

Do not inject into areas where the skin is tender, bruised, red or hard. Avoid injecting into areas with scars or stretch marks.

If you have psoriasis, you should avoid injecting directly into raised, thick, red or scaly skin patches or lesions.

Step 2: Get ready

A. Pull the white cap straight off only when you’re ready to inject.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL
  • It is normal to see a drop of liquid at the end of the needle or green safety guard
  • Do not twist, bend or wiggle the white cap
  • Do not put the white cap back onto the autoinjector
  • Do not put fingers into the green safety guard
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Do not remove the white cap from the autoinjector until you’re ready to inject.

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Do not leave the white cap off for more than five minutes.

If you are unable to inject, please contact your healthcare provider.

B. Stretch or pinch your injection site to create a firm surface.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL

Stretch skin firmly by moving your thumb and fingers in opposite directions, creating an area about 2 inches wide.

OR

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL

Pinch skin firmly between your thumb and fingers, creating an area about 2 inches wide.

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It is important to keep skin stretched or pinched while injecting.

Step 3: Inject

A. Hold, stretch or pinch. With the white cap off, PLACE the green safety guard on the skin at 90 degrees. The needle is inside the green safety guard.

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Do not touch the purple start button yet.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL

B. Firmly PUSH the autoinjector down onto the skin until it stops moving.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL
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You must push all the way down but DO NOT touch the purple start button until you’re ready to inject.

C. When you’re ready to inject, PRESS the purple start button. You will hear a click.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL

D. Keep PUSHING the autoinjector down on your skin. Then lift your thumb while still holding the autoinjector on your skin. Your injection could take about 15 seconds to complete.

ENBREL SureClick autoinjector illustration labelled white cap, window and ENBREL

Important: When you remove the autoinjector, if the window has not turned yellow, or if it looks like the medicine is still injecting, this means you have not received a full dose. Call your healthcare professional immediately.

Step 4: Finish

A. Throw away the used autoinjector and the white needle cap.

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Put the used autoinjector and white needle cap in a sharps disposal container right away after use. Do not throw away the SureClick Autoinjector in your household trash.

If you do not have a sharps disposal container, you may use a household container that is:

  • Made of a heavy-duty plastic;
  • Can be closed with a tight-fitting, puncture-resistant lid without sharps being able to come out;
  • Upright and stable during use;
  • Leak-resistant; and
  • Properly labeled to warn of hazardous waste inside the container.

When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of it. There may be local laws about how you should throw away used needles and syringes.

Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.

Important: Always keep the sharps disposal container out of the reach of children.

  • Do not reuse the autoinjector.
  • Do not recap the autoinjector or put fingers into the green safety guard.

B. Check the injection site.

If there is blood, press a cotton ball or gauze pad on your injection site. Apply an adhesive bandage if needed. Do not rub injection site.

To order a sharps disposal container, call the Amgen Entrust Patient Support Program at 1.877.9ENBREL (1.877.936.2735), weekdays 8:00 am to 8:00 pm EST.

All questions should be handled by a doctor, nurse or pharmacist familiar with ENBREL. A toll-free information service is also available: 1.877.9ENBREL (1.877.936.2735), weekdays 8:00 am to 8:00 pm EST.