Introduction to ENBREL Lyophilized Powder

There are two methods for preparing ENBREL solution: one for single-use administration (vial adapter method) and one for multiple-use administration in children (free-hand method).

Vial adapter method:

• Adult patients and children who use an entire vial of ENBREL should use the vial adapter device to assist in mixing the powder with the liquid and withdrawing ENBREL. A 27-gauge needle should be attached to the syringe to inject the dose. You should not use the vial adapter method if you will be using the vial more than once. This method should not be used for children withdrawing multiple doses from the same vial of ENBREL. For instructions on using the vial adapter method, click here.

Free-hand method:

• For some children, one vial of ENBREL solution can be used for more than one dose. This method should be used for multiple-use administration in children on ENBREL, using a 25-gauge needle to assist with mixing the powder with the liquid and switching to a 27-gauge needle to inject the dose. For instructions on using the free-hand method, click here.

Please consult your doctor about the appropriate method to use to prepare an ENBREL dose for injection.